A marine-derived acidic oligosaccharide sugar chain specifically inhibits neuronal cell injury mediated by β-amyloid-induced astrocyte activation in vitro
Authors: Wang, Shaohua1; Li, Jing1; Xia, Wei1; Geng, Meiyu1
Source: Neurological Research, Volume 29, Number 1, January 2007 , pp. 96-102(7)
Publisher: Maney Publishing
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Abstract:
In Alzheimer's disease (AD), β-amyloid (Aβ) plaques are surrounded by activated astrocytes and microglia. A growing body of evidence suggests that these activated astrocytes contribute to neurotoxicity through the induction of inflammatory cytokines and the production of oxidative stress mediators. Thus, a compound inhibiting Aβ-induced activation of astrocytes may lead to a novel therapy for AD. Our current work investigates the roles of acidic oligosaccharide sugar chain (AOSC), derived from brown algae Echlonia Kurome Okam, on Aβ-induced inflammatory responses and cytotoxicity. We observed that AOSC inhibited the toxicity and apoptosis in SH-SY5Y cell line induced by Aβ-stimulated astrocytes conditioned medium. We found that AOSC inhibited the reactive phenotype of astrocytes, blocked cellular oxidative stress, reduced the production of tumor necrosis factor (TNF)-α and interleukin (IL)-6 and prevented the influx of Ca2+. Thus, our results indicate that AOSC might be a potentially therapeutic compound for AD.Keywords: ALZHEIMER'S DISEASE; AMYLOID BETA PROTEIN; ASTROCYTE; INFLAMMATION; AOSC
Document Type: Research article
DOI: 10.1179/174313206X152483
Affiliations: 1: Department of Pharmacology, Marine Drug and Food Institute, Ocean University of China, Qingdao 266003, China
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