Home >> Neurological Research, Volume 27, Supplement 1

Partial aortic obstruction improves cerebral perfusion and clinical symptoms in patients with symptomatic vasospasm

Authors: Lylyk, Pedro; Vila, José; Miranda, Carlos; Ferrario, Angel; Romero, Ricardo; Cohen, José

Source: Neurological Research, Volume 27, Supplement 1, October 2005 , pp. 129-135(7)

Publisher: Maney Publishing

Buy & download fulltext article:

OR

Price: $48.00 plus tax (Refund Policy)

Abstract:

Objective: Stroke studies in animals showed that aortic obstruction increases cerebral blood flow (CBF) and reduces infarct size. In this study we evaluate the safety and efficacy of a device providing partial and transitory aortic obstruction.

Methods: We report the results in 24 selected patients with symptomatic vasospasm by aneurysmal subarachnoid hemorrhage treated by partial and transitory aortic obstruction with a novel device (NeuroFlo?, CoAxia, MN). Aneurysms were secured by coils prior to the procedure. We studied the adverse effects related to the aorta-obstructing device, and changes in CBF and neurological outcome.

Results: Mean flow velocity increased in both middle cerebral arteries over 15%, and the score in the National Institute of Health Stroke Scale decreased ?2 point in 20 patients (83%). During the procedure, three patients developed symptoms that were controlled. At 30 days follow-up, three patients had 6 points (unrelated death), three had 3 points, six had 1 point, and 12 had 0 points, in the modified Rankin scale.

Discussion: Partial aortic obstruction was safe, the cerebral blood flow increased without inducing significant hypertension and the neurological defects improved in most of the patients. Efficacy with a better level of evidence will be determined by a randomized study.

Keywords: SYMPTOMATIC VASOSPASM; CONTROLLED AORTIC OBSTRUCTION; SUBARACHNOID HEMORRHAGE; VASOSPASM; VASOSPASM TREATMENT

Document Type: Research Article

DOI: http://dx.doi.org/10.1179/016164105X35512

Affiliations: Department of Neurosurgery, Endovascular Neurosurgery and Interventional Neuroradiology, ENERI Clínica Médica Belgrano Buenos Aires, Argentina

Publication date: 2005-10-01

More about this publication?
Related content
Marked list

Tools

Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content

Text size:

A | A | A | A
^ Back to top
Share this item with others: These icons link to social bookmarking sites where readers can share and discover new web pages. print icon Print this page