Authors: Aoun, Peter; Jones, Timothy; Shaw, Gordon; Bodner, Mark

Source: Neurological Research, Volume 27, Number 8, December 2005 , pp. 791-796(6)

Publisher: Maney Publishing

Abstract:

Objectives: An animal model of the 'generalized Mozart effect' (GME) – enhanced/normalized higher brain function in response to music exposure – has been established. We extend those results in two studies using another species (mice). Study 1: (1) maze testing after music exposure was extended to a minimum of 6 hours; (2) no exposure to music in utero. Study 2: (1) music exposure time further reduced; (2) maze testing extended to 24 hours.

Methods: Study 1: two mouse groups were exposed to music continuously for 10 hours per day for 10 weeks (Group I: Mozart's Sonata K.448, Group II: Beethoven's Fur Elise). After 10 weeks, the ability to negotiate a T-maze was assessed (recording working time in maze, number of errors). Maze ability was tested 6 hours following the last music exposure. Study 2: two mouse groups were exposed periodically to music (58% silence) 10 hours per day for 10 weeks. Experiments after 10 weeks examined the groups' abilities to run the maze (recording working time/errors). Experiments were conducted 24 hours following the last music exposure.

Results: The Mozart group exhibited significant enhancements compared with the control mice in both studies, i.e. significantly lower working time (p<0.05) and committed fewer errors.

Discussion: Observation of GME in another species supports its generality for the mammalian cortex. The absence of a GME in fMRI studies for the control music also indicates a neurophysiological basis. With extended exposure, GME is a long-term effect, indicating potential clinical importance. It has been demonstrated that GME reduces neuropathological spiking significantly in epileptics. We discuss the relevance of this study for epilepsy treatment.

Keywords: EEG; EPILEPSY; CORTICAL COLUMN; FMRI; TRION MODEL OF CORTEX

Document Type: Research Article

DOI: http://dx.doi.org/10.1179/016164105X63647

Affiliations: MIND Institute, 1503 South Coast Drive, Costa Mesa, CA 92626, USA

Publication date: 2005-12-01

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