Abstract:

Objective: Our aim was to explore whether free radical damage against DNA exists or not, in human stroke patients.

Method: Urinary 8-hyroxy-2-deoxyguanosine (8-OHdG) and serum S100 were measured in acute cardioembolic stroke patients with relatively severe symptoms. During days 3–5 after the onset of stroke, urine was collected for 24 hours for 8-OHdG measurement and serum was sampled for S100 analysis every day.

Results: The total urinary 8-OHdG content was significantly higher in stroke patients than in non-stroke inpatients (p<0.01). The average value was more than twice the value of that of non-stroke inpatients. The total urinary 8-OHdG contents showed significant correlation (r=0.87, p<0.01) with serum S100 values, which are reportedly related to brain damage.

Discussion: These findings suggest that urinary 8-OHdG in acute stroke patients may originate from brain tissue, and DNA damage also exists in the brain of stroke patients.

Keywords: 8-OHDG; S100BETA; STROKE PATIENTS; DNA; FREE RADICAL

Document Type: Research article

DOI: 10.1179/016164105X25153

Affiliations: 1: The Second Department of Internal Medicine, Nippon Medical School, Tokyo, Japan