Authors: Bailey, Thomasina¹; Rivara, Claire¹; Rocher, Anne¹; Hof, Patrick²

Source: Neurological Research, Volume 26, Number 5, July 2004 , pp. 573-578(6)

Publisher: Maney Publishing

Abstract:

Age-related and amyloid-induced pathology of the cerebral microvasculature have been implicated as potential contributing factors to the pathogenesis of Alzheimer's disease (AD). The microvasculature plays a crucial role in maintaining brain homeostasis and deterioration of its integrity may have deleterious effects on brain function in AD, possibly leading to neurofibrillary degeneration, plaque formation, and cell loss. Brain vessels possess peculiar anatomical and physiological properties owing to their role in the exchange processes of various substances between blood and brain, which are highly regulated for the maintenance of ionic homeostasis of the neuronal environment. Here we review neuropathological aspects of cortical microvessels in aging and AD in relationship to known cardiovascular risk factors and their possible impact on the cognitive decline seen in late-onset dementia.

Keywords: CEREBRAL CORTEX; BRAIN AGING; DEMENTIA; CAPILLARIES; CEREBRAL MICROVASCULATURE; AMYLOID ANGIOPATHY

Document Type: Research Article

DOI: http://dx.doi.org/10.1179/016164104225016272

Affiliations: 1: Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology 2: Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology and Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York NY 10029, USA

Publication date: 2004-07-01

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