Home >> Neurological Research, Volume 26, Number 1

Spatial learning transiently disturbed by intraventricular administration of ouabain

Authors: Zhan, Hua; Tada, Tsuyoshi; Nakazato, Fumi; Tanaka, Yuichiro; Hongo, Kazuhiro

Source: Neurological Research, Volume 26, Number 1, January 2004 , pp. 35-40(6)

Publisher: Maney Publishing

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Abstract:

The presence of sodium?potassium?adenosine triphosphatase (Na+,K+-ATPase) on the surface of arachnoid cells indicates that active transport of electrolytes and water occurs there. Previously, we accidentally found that intraventricular administration of TGF-?1 impaired rat spatial learning. Levels of Na+,K+-ATPase were decreased in arachnoid cells with fibrosis. To characterize the role of the Na+,K+-ATPase, Wistar rats were intraventricularly administered a total of 200 ?l of ouabain, at concentrations of 10-5, 10-4 and 10-3 M, for one week with an osmotic pump, and were examined with a Morris water maze. Latency for reaching the platform did not significantly differ between ouabain-administered rats and controls. Spatial learning was impaired in a dose-dependent manner. Na+,K+-ATPase activity of arachnoid cells ceased during ouabain administration, and recovered completely three weeks after the end of ouabain administration. The present results suggest that the Na+,K+-ATPase on the surface of arachnoid cells contributes to maintenance of rat spatial learning.

Keywords: SPATIAL LEARNING; ARACHNOID CELL; OUABAIN; RAT; NA+,K+-ATPASE; MORRIS WATER MAZE

Document Type: Research Article

DOI: http://dx.doi.org/10.1179/016164104773026507

Affiliations: Department of Neurosurgery, Shinshu University School of Medicine, Matsumoto, Japan

Publication date: 2004-01-01

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