Omental transpositionto the brain as a surgical method for treating Alzheimer's disease

Authors: Goldsmith, Harry S.; Wu, Weilie; Zhong, Jun; Edgar, Mark

Source: Neurological Research, Volume 25, Number 6, September 2003 , pp. 625-634(10)

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Abstract:

The purpose of this study was to learn the effect of omental transposition to the brain of patients who exhibited the most serious effects of long-standing Alzheimer's disease. Ten patients who had extremely low Mini Mental-State Examination scores of 2-14 underwent placement of their elongated pedicled omentum onto their left parietal-temporal cerebral cortex. Patients underwent pre- and post-operative MRI and SPECT scans in addition to long-term neurological and neuropsychological testing. All were followed up to one year. In spite of the patients' severe cognitive and functional disability, several of the patients demonstrated subjective and objective improvement, especially in terms of their functional status.

Keywords: CEREBRAL BLOOD FLOW; CEREBRAL HYPOPERFUSION; ALZHEIMER'S DISEASE; OMENTUM TRANSPOSITION

Document Type: Research Article

DOI: http://dx.doi.org/10.1179/016164103101201922

Affiliations: Department of Surgery, University of Nevada School of Medicine, Reno, NV, USA

Publication date: 2003-09-01

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