Future of extracranial–intracranial bypass

Authors: Guthikonda, Murali; Guyot, Lisa; Diaz, Fernando

Source: Neurological Research, Volume 24, Supplement 1, April 2002 , pp. 80-83(4)

Publisher: Maney Publishing

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Abstract:

Total occlusion of internal carotid artery in the cervical region is an end result of progressive occlusive vascular disease. A small proportion of these patients will have symptoms of cerebral ischemia due to cerebral hypoperfusion in a delayed fashion. Identification of those individuals who are at risk of developing symptoms and prophylactically treating with a revascularization procedure will prevent such catastrophic events. With the co-operative study for bypass not supporting the bypass procedure and trial being questioned for its design and conclusions, a new trial of extracranial-intracranial bypass, The Carotid Occlusion Surgery Study, using the currently available technology will be undertaken to verify that the bypass will decrease the future stroke rate by at least 40% in patients with total carotid occlusion. A subset of patients with skull base pathology including tumors and aneurysms who may have to undergo carotid sacrifice as part of the surgical procedure are at risk of peri-operative and delayed stroke. Identification of these patients at risk by pre-operative tests may allow performance of extracranial-intracranial bypass prior to undertaking complex skull base procedures. The new imaging technology will guide management of these patients at risk and help identify patients who may need a bypass procedure. [Neurol Res 2002; 24: S80-S83]

Keywords: CAROTID OCCLUSION; STUDY; CEREBRAL REVASCULARIZATION; CAROTID OCCLUSION SURGERY; EXTRACRANIAL-INTRACRANIAL BYPASS

Document Type: Research Article

DOI: http://dx.doi.org/10.1179/016164102101199954

Affiliations: Department of Neurological Surgery, Wayne State University, Detroit, MI, USA

Publication date: 2002-04-15

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