Home >> Nutritional Neuroscience, Volume 15, Number 1

Dietary supplementation with decaffeinated green coffee improves diet-induced insulin resistance and brain energy metabolism in mice

Authors: Ho, Lap1; Varghese, Merina1; Wang, Jun1; Zhao, Wei1; Chen, Fei1; Knable, Lindsay Alexis1; Ferruzzi, Mario2; Pasinetti, Giulio M.1

Source: Nutritional Neuroscience, Volume 15, Number 1, January 2012 , pp. 37-45(9)

Publisher: Maney Publishing

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Abstract:

Objectives:

There is accumulating evidence that coffee consumption may reduce risk for type 2 diabetes, a known risk factor for Alzheimer's and other neurological diseases. Coffee consumption is also associated with reduced risk for Alzheimer's disease and non-Alzheimer's dementias. However, preventive and therapeutic development of coffee is complicated by the cardiovascular side effects of caffeine intake. As coffee is also a rich source of chlorogenic acids and many bioactive compounds other than caffeine, we hypothesized that decaffeinated coffee drinks may exert beneficial effects on the brain.

Methods:

We have investigated whether dietary supplementation with a standardized decaffeinated green coffee preparation, Svetol®, might modulate diet-induced insulin resistance and brain energy metabolism dysfunction in a high-fat diet mouse model.

Results:

As expected, dietary supplementation with Svetol® significantly attenuated the development of high-fat diet-induced deficits in glucose-tolerance response. We have also found that Svetol® treatment improved brain mitochondrial energy metabolism as determined by oxygen consumption rate. Consistent with this evidence, follow-up gene expression profiling with Agilent whole-genome microarray revealed that the decaffeinated coffee treatment modulated a number of genes in the brain that are implicated in cellular energy metabolism.

Discussion:

Our evidence is the first demonstration that dietary supplementation with a decaffeinated green coffee preparation may beneficially influence the brain, in particular promoting brain energy metabolic processes.

Keywords: Chlorogenic acid; Coffee; Dementia; Alzheimer's disease; Mitochondria; Alzheimer's disease

Document Type: Research Article

DOI: http://dx.doi.org/10.1179/1476830511Y.0000000027

Affiliations: 1: Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA 2: Departments of Food Science and Foods & Nutrition, Purdue University, West Lafayette, IN, USA

Publication date: 2012-01-01

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