Home >> Nutritional Neuroscience, Volume 13, Number 6

Effects of intra-uterine and early extra-uterine malnutrition on seizure threshold and hippocampal morphometry of pup rats

Authors: Florian, Mariana Lorenzet1; Nunes, Magda Lahorgue2

Source: Nutritional Neuroscience, Volume 13, Number 6, December 2010 , pp. 265-273(9)

Publisher: Maney Publishing

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Abstract:

We evaluate the influence of different malnutrition paradigms (intra-uterine × extra-uterine) in body and brain weight, in seizure threshold and in hippocampus morphometry, in developing rats. Intra-uterine malnutrition model consisted in reduction by half of the ration offered to pregnant female; extra-uterine malnutrition consisted of progressive limitation of lactation, from P2 to P15. Seizure induction was accomplished by exposure to flurothyl, at P15. At the same day animals were sacrificed. Morphometric analysis was based on hippocampal pyramidal and granular cells estimate number, through volume calculation and cellular density. Extra-uterine malnutrition significantly reduced pups body and brain weight, seizure threshold and neuronal number in CA4 region only. Intra-uterine malnutrition reduced neuronal number in CA2, CA4 and DG regions regarding well-nourished and extra-uterine malnourished animals. In CA3, CA4 and dentate gyrus, a significant cell increase was observed in groups exposed to seizures, regarding similar control groups.

Keywords: EARLY MALNUTRITION; SEIZURE; HIPPOCAMPUS; MORPHOMETRY; RODENT MODEL

Document Type: Research article

DOI: http://dx.doi.org/10.1179/147683010X12611460764804

Affiliations: 1: Neurosciences Laboratory, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) School of Medicine, Porto Alegre, RS, Brazil 2: Neurosciences Laboratory, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) School of Medicine, Porto Alegre, RS, Brazil, Division of Neurology, Hospital São Lucas, PUCRS, AvenidaIpiranga 6690, Jardim Botânico, sala 322, 90610-000, Porto Alegre, RS, Brazil. nunes@pucrs.br

Publication date: 2010-12-01

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