Home >> Nutritional Neuroscience, Volume 13, Number 1

Central L-ornithine, but not polyamines, induces a hypnotic effect in neonatal chicks under acute stress

Authors: Kurauchi, Isao1; Shigemi, Kazutaka1; Kabuki, Yusuke1; Hamasu, Kousuke1; Yamane, Haruka1; Aoki, Mami2; Kawada, Yoko2; Morishita, Koji2; Denbow, D. Michael3; Furuse, Mitsuhiro4

Source: Nutritional Neuroscience, Volume 13, Number 1, February 2010 , pp. 17-20(4)

Publisher: Maney Publishing

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Abstract:

To clarify whether L-ornithine and/or its metabolite involves sedative and hypnotic effects under social separation stress, the effects of intracerebroventricular (i.c.v.) injection of L-ornithine and polyamines (putrescine, spermidine and spermine) were compared in chicks. Birds were injected i.c.v. with 0.5 ?mol of L-ornithine, putrescine, spermidine, spermine or saline (control). After injection, chicks were immediately separated from the flock and monitored for the number of distress vocalizations and various postures. L-Ornithine greatly attenuated the stress response and caused sedative and hypnotic effects. Among the polyamines, only putrescine attenuated distress vocalizations but did not induce sleep. In conclusion, the sedative and hypnotic effect of L-ornithine was mainly induced by L-ornithine itself, while the polyamines contributed to the sedative, but not hypnotic, effect under social separation stress.

Keywords: POLYAMINE; NEONATAL CHICK; INTRACEREBROVENTRICULAR INJECTION; L-ORNITHINE; SOCIAL SEPARATION STRESS; PUTRESCINE

Document Type: Research Article

DOI: http://dx.doi.org/10.1179/147683010X12611460763481

Affiliations: 1: Laboratory of Regulation in Metabolism and Behavior, Graduate School of Bioresources and Bioenvironmental Sciences, Kyushu University, Fukuoka, Japan 2: Healthcare Products Development Center, Kyowa Hakko Bio Co., Ltd, Tsukuba, Japan 3: Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA 4: Laboratory of Regulation in Metabolism and Behavior, Graduate School of Bioresources and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan. furuse@brs.kyushu-u.ac.jp

Publication date: 2010-02-01

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