Authors: Kirac, Deniz¹; Ozden, Inci¹; Yildirim, Alper²; Genç, Ece³

Source: Nutritional Neuroscience, Volume 12, Number 2, April 2009 , pp. 89-94(6)

Publisher: Maney Publishing

Abstract:

The aim of the present study was to investigate whether high fat consumption changes the effects of stress on both motor activity performance, striatal and cortical dopamine and serotonin metabolites in rats. The animals were fed either with high fat or standard diet for 4 weeks. Restraint stress lasting for 15 min at +4?C was applied daily to stress-exposed groups. Motor activity performance was measured weekly by using motor activity monitoring systems. At the end of the study, homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) levels of the striatum and cerebral cortex were measured by HPLCEC. It was observed that restraint stress increased locomotor activity and high-fat diet prevented this effect. Stress and high-fat intake had an additive decreasing effect on striatal HVA levels. 5-HIAA levels, on the other hand, were lower in both high fat and high fat + stress groups compared to the stress group. These results suggest that high-fat intake differentially affected the stress response on striatal dopaminergic and serotonergic neurons in rat brain regions studied and this may be related to the effects observed in motor activity performance.

Keywords: RESTRAINT STRESS; MOTOR ACTIVITY; HVA; 5-HIAA; HIGH-FAT DIET

Document Type: Research Article

DOI: http://dx.doi.org/10.1179/147683009X423256

Affiliations: 1: Department of Biochemistry, Faculty of Medicine, Yeditepe University, Istanbul, Turkey 2: Department of Physiology, Faculty of Medicine, Yeditepe University, Istanbul, Turkey 3: Department of Pharmacology, Faculty of Medicine, Yeditepe University, Istanbul, Turkey

Publication date: 2009-04-01

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