Authors: Sánchez, Cristina¹; Cubero, Javier¹; Sánchez, Javier²; Chanclón, Belén¹; Rivero, Montserrat³; Rodríguez, Ana¹; Barriga, Carmen¹

Source: Nutritional Neuroscience, Volume 12, Number 1, February 2009 , pp. 2-8(7)

Publisher: Maney Publishing

Abstract:

Breast-milk contains a potent mixture of diverse components, such as the non-protein nitrogen fraction which includes nucleotides, whose variation in levels is evident throughout lactation. In addition, these substances play an important role in sleep homeostasis. In the present study, human milk samples were analyzed using a capillary electrophoresis system. The rhythmicity of each nucleotide was studied by cosinor analysis. It was found that the nucleotides 5′AMP, 5′GMP, 5′CMP, and 5′IMP have significant (P < 0.05) circadian rhythms, the acrophases of the first two being during the night, and of the latter two during the day. While 5′UMP did not show a clear circadian rhythm, there was an increase in its levels at night. In conclusion, the rise in nocturnal levels of 5′AMP, 5′GMP, and 5′UMP could be involved in inducing the 'hypnotic' action of breast-milk at night in the infant.

References: 34 references open in new window

Articles that cite this article?

Keywords: HUMAN MILK; NUCLEOTIDES; CIRCADIAN; CAPILLARY ELECTROPHORESIS; SLEEP

Document Type: Research Article

DOI: http://dx.doi.org/10.1179/147683009X388922

Affiliations: 1: Department of Physiology, Faculty of Science, University of Extremadura, Badajoz, Spain 2: Laboratory of Metabolism, Hospital 'Perpetuo Socorro', Badajoz, Spain 3: Ordesa Group, St Boi de Llobregat, Barcelona, Spain

Publication date: 2009-02-01

More about this publication?

• Editorial Board
• Information for Authors
• Submit a Paper
• Subscribe to this Title
• Information for Advertisers
• Terms & Conditions
• Top Articles
• Health Sciences Spotlight
• Virtual Maney - Stroke
• ingentaconnect is not responsible for the content or availability of external websites

Related content

• In this: publication
• By this: publisher
• In this Subject: Neurology & Psychiatry
• By this author: Sánchez, Cristina ;  Cubero, Javier ;  Sánchez, Javier ;  Chanclón, Belén ;  Rivero, Montserrat ;  Rodríguez, Ana ;  Barriga, Carmen

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers