Harris-Benedict equation estimations of energy needs as compared to measured 24-h energy expenditure by indirect calorimetry in people with early to mid-stage Huntington's disease

Authors: Gaba, Ann¹; Zhang, Kuan²; Moskowitz, Carol B.³; Boozer, Carol N.⁴; Marder, Karen⁵

Source: Nutritional Neuroscience, Volume 11, Number 5, October 2008 , pp. 213-218(6)

Publisher: Maney Publishing

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Abstract:

Weight loss and energy metabolism are important clinical research areas in understanding the disease mechanisms in Huntington's disease. Having an accurate method to estimate expected total energy expenditure would likely facilitate the development of studies about these features of the disease. The Harris-Benedict equation is a formula commonly used to estimate basal energy expenditure of individuals, adjusted for height, weight, age and gender. This estimate is then multiplied by a physical activity factor to estimate total daily energy needs to maintain the given weight. Data from 24-h indirect calorimetry was utilized to derive an adjustment formula for the physical activity factor of the Harris-Benedict equation for 13 early to mid-stage Huntington's disease patients. The adjusted activity factor provided the most accurate estimate of energy needs. This adjusted formula can be used in clinical assessments of Huntington's disease patients, as well as in research studies when indirect calorimetry has not been performed.

Keywords: HUNTINGTON'S DISEASE; ENERGY REQUIREMENTS; HARRIS-BENEDICT EQUATION

Document Type: Research article

DOI: 10.1179/147683008X344129

Affiliations: 1: Department of Food and Nutrition Services, New York Presbyterian Hospital, New York, USA 2: Obesity Research Center, St Luke's-Roosevelt Hospital Center, New York, USA; The Institute of Human Nutrition, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, USA 3: Obesity Research Center, St Luke's-Roosevelt Hospital Center, New York, USA 4: The Institute of Human Nutrition, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, USA; The Institute of Human Nutrition, Department of Neurology, Columbia University College of Physicians and Surgeons, Ne 5: The Institute of Human Nutrition, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, USA; The Institute of Human Nutrition, Department of Psychiatry, Columbia University College of Physicians and Surgeons,

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