Authors: Jorissen, B.L.¹; Brouns, F.²; Van Boxtel, M.P.J.¹; Riedel, W.J.¹

Source: Nutritional Neuroscience, Volume 5, Number 5, January 2002 , pp. 337-343(7)

Publisher: Maney Publishing

Abstract:

Phosphatidylserine (PS) is a phospholipid which has been claimed to enhance neuronal membrane function, and can be derived from several sources. Earlier studies used brain cortex derived PS, of which the human tolerability of 300 mg daily in 130 patients has been shown. The human tolerability of PS derived from soy-bean has not been reported, although it is widely sold as a nutritional supplement which may improve cognitive function in the elderly. We report the results of a study of the safety of two dosages of soy-phosphatidylserine (S-PS) in elderly.

Subjects were 120 elderly of both sexes who fulfilled the more stringent criteria for age-associated memory impairment; some also fulfilled the criteria for age-associated cognitive decline. Subjects were allocated at random to one of the three treatment groups: placebo, 300 or 600 mg S-PS daily. Standard biochemical and hematological safety parameters, blood pressure, heart rate and adverse events were assessed at baseline, after 6 and 12 weeks of treatment.

No significant differences were found in any of the outcome variables between the treatment groups after Bonferonni-Holme correction.

In conclusion, soy derived PS is a safe nutritional supplement for older persons if taken up to a dosage of 200 mg three times daily.

Keywords: Nutritional supplement; Side effects; Age-associated memory impairment; Phosphatidylserine; Phospholipid; Safety

Document Type: Research Article

DOI: http://dx.doi.org/10.1080/1028415021000033802

Affiliations: 1: Experimental Psychopharmacology Unit, Department of Psychiatry and Neuropsychology, Brain and Behaviour Institute, Universiteit Maastricht, P.O. Box 616, 6200 MD Maastricht, The Netherlands 2: Novartis Nutrition Research Unit, Department of Psychiatry and Neuropsychology, Universiteit Maastricht, P.O. Box 616, 6200 MD Maastricht, The Netherlands

Publication date: 2002-01-01

More about this publication?

• Editorial Board
• Information for Authors
• Submit a Paper
• Subscribe to this Title
• Information for Advertisers
• Terms & Conditions
• Top Articles
• Health Sciences Spotlight
• Virtual Maney - Stroke
• ingentaconnect is not responsible for the content or availability of external websites

Related content

• In this: publication
• By this: publisher
• In this Subject: Neurology & Psychiatry
• By this author: Jorissen, B.L. ;  Brouns, F. ;  Van Boxtel, M.P.J. ;  Riedel, W.J.

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers