Stem cell behaviours and functions modulated by biomaterials

Authors: He, H. X.; Liu, H. C.

Source: Materials Technology: Advanced Performance Materials, Volume 25, Numbers 3-4, September 2010 , pp. 231-236(6)

Publisher: Maney Publishing

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Abstract:

Stem cells have shown the great potential as a candidate for tissue engineering and regenerative medicine. However, the main challenge must be overcome about the controlled regulation of stem cell growth and differentiation before its wide clinical applications. Recent advances in biomaterial engineering and scaffold fabrication may provide a powerful tool towards solving this problem. In this article, silk based biomaterials, nanoscale biomaterials and polymer–ceramic hybrid composites are introduced which represent the new biomaterials in the field of tissue engineering. Moreover, researchers have incorporated signals directly into the biomaterials by novel processing techniques such as surface modification techniques, self- assembly process and rapid prototyping techniques. Additionally, we review the recent research in the area of high throughput approaches towards characterisation and optimisation of stem cell–material interactions and discuss the future directions of biomaterials in tissue engineering.

Keywords: STEM CELL; TISSUE ENGINEERING; BIOMATERIAL

Document Type: Research Article

DOI: http://dx.doi.org/10.1179/175355510X12723642365205

Affiliations: Institute of Dental Research, Chinese PLA General Hospital and Postgraduate Military Medical School, Beijing 100853, China

Publication date: 2010-09-01

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