Chemosensitization Effects of XIAP Downregulation in K562 Leukemia Cells
Authors: Lima, R.T.; Martins, L.M.; Guimarães, J.E.; Sambade, C.; Vasconcelos, M.H.
Source: Journal of Chemotherapy, Number 1, February 2006 , pp. 98-102(5)
Publisher: Maney Publishing
Abstract:The effect of downregulation of the expression of the antiapoptotic protein XIAP with antisense oligonucleotides was evaluated in the K562 chronic myeloid leukemia (CML) cell line. This was carried out by studying the effects of downregulation of XIAP expression on cellular viability, cellular apoptosis and on the response to two chemotherapeutical drugs, etoposide and doxorubicin. We document that downregulation of XIAP expression decreased cellular viability, increased cellular apoptosis and enhanced the effects of doxorubicin.
Document Type: Research Article
Publication date: 2006-02-01