Use of continuous venovenous hemofiltration for acute renal failure due to multiple myeloma cast nephropathy

Authors: Mehta, Suchita¹; Shtaynberg, Norbert²; Goldman, Michael²; Asti, Deepak¹; Kiroycheva, Militza²; Pepe, John²

Source: Hematology, Volume 17, Number 4, July 2012 , pp. 229-231(3)

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Abstract:

Renal insufficiency is associated with high morbidity and mortality in multiple myeloma. One of the common causes for acute renal failure in multiple myeloma is cast nephropathy. It is important to reduce the levels of light chains to improve renal failure and also the overall outcome. Plasmapheresis has failed to show any significant improvement in renal failure due to cast nephropathy as demonstrated in a recent randomized control trial. Here, we present a case series of three patients who were treated with continuous venovenous hemofiltration as a modality to remove these free light chains. There was improvement in renal failure in these patients with decrease in the levels of free light chains. These patients remained off hemodialysis on follow-up and two of them were able to undergo hematopoietic stem cell transplantation.

Keywords: Multiple myeloma; Cast nephropathy; Renal failure; CVVH

Document Type: Case report

DOI: http://dx.doi.org/10.1179/1607845412Y.0000000003

Affiliations: 1: Department of Medicine, Staten Island University Hospital, Staten Island, NY, USA 2: Division of Nephrology, Staten Island University Hospital, Staten Island, NY, USA

Publication date: 2012-07-01

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