Hematopoietic stromal cells and megakaryocyte development
Authors: Feng, Yimei; Gao, Lei; Chen, Xinghua
Source: Hematology, Volume 16, Number 2, March 2011 , pp. 67-72(6)
Publisher: Maney Publishing
The hematopoietic microenvironment, and in particular the hematopoietic stromal cell element, are intimately involved in megakaryocyte development. The process of megakaryocytopoiesis occurs within a complex bone marrow microenvironment where adhesive interactions, chemokines, as well as cytokines play a pivotal role. Here we review the effect of stromal cells and cytokines on megakaryocytopoiesis with the aim of exploring new therapeutic strategies for platelet recovery after hematopoietic stem cell transplantation (HSCT).
Document Type: Research Article
Affiliations: Department of Hematology, Second Affiliated Hospital, Third Military Medical University, Chongqing, China
Publication date: 2011-03-01