Unusual extramedullary recurrences and breast relapse despite hepatic GVHD after allografting in Ph+-ALL
Source: Hematology, Volume 11, Number 2, April 2006 , pp. 105-107(3)
Publisher: Maney Publishing
Abstract:Extramedullary recurrences with or without bone marrow involvement are reported in up to a half of leukemic relapses after BMT. Our report describes a case of an extramedullary recurrence and breast relapse after second-allografting in a female patient with Ph+-acute lymphoblastic leukemia (ALL), occurring when there was active hepatic GHVD. This case illustrates the complex relationship between graft-versus-host disease (GVHD) and graft-versus-leukemia since she had no evidence of leukemia in her marrow demonstrating 100% full-donor chimerism while she had ALL relapse in her breast.
Document Type: Research Article
Affiliations: 1: Division of Hematology, Department of Internal Medicine, Hacettepe University, Ankara, Turkey 2: Department of Internal Medicine, Hacettepe University, Ankara, Turkey 3: Department of Pathology, Hacettepe University, Ankara, Turkey
Publication date: 2006-04-01