Unusual extramedullary recurrences and breast relapse despite hepatic GVHD after allografting in Ph⁺-ALL

Authors: Koca, Ebru¹; Goker, Hakan¹; Guven, Gulay S.²; Cetiner, Deniz¹; Haznedaroglu, Ibrahim C.¹; Buyukasik, Yahya¹; Uner, Aysegul³; Ozcebe, Osman I.¹

Source: Hematology, Volume 11, Number 2, April 2006 , pp. 105-107(3)

Publisher: Maney Publishing

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Abstract:

Extramedullary recurrences with or without bone marrow involvement are reported in up to a half of leukemic relapses after BMT. Our report describes a case of an extramedullary recurrence and breast relapse after second-allografting in a female patient with Ph⁺-acute lymphoblastic leukemia (ALL), occurring when there was active hepatic GHVD. This case illustrates the complex relationship between graft-versus-host disease (GVHD) and graft-versus-leukemia since she had no evidence of leukemia in her marrow demonstrating 100% full-donor chimerism while she had ALL relapse in her breast.

Keywords: EXTRAMEDULLARY RELAPSE; BREAST; ACUTE LYMPHOBLASTIC LEUKEMIA; GRAFT-VERSUS HOST DISESASE; ALLOGENEIC STEM CELL TRANSPLANTATION

Document Type: Research Article

DOI: http://dx.doi.org/10.1080/10245330600574177

Affiliations: 1: Division of Hematology, Department of Internal Medicine, Hacettepe University, Ankara, Turkey 2: Department of Internal Medicine, Hacettepe University, Ankara, Turkey 3: Department of Pathology, Hacettepe University, Ankara, Turkey

Publication date: 2006-04-01

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