Alternating hemiplegia of childhood: successful treatment with topiramate and flunarizine, a case report

Authors: Aishworiya, R; Low, P S; Tay, S K H

Source: Annals of Tropical Paediatrics: International Child Health, Volume 31, Number 2, May 2011 , pp. 149-152(4)

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Abstract:

Alternating hemiplegia of childhood (AHC) is a rare neurological disorder which usually presents before 18 months of age and is characterised by recurrent alternating episodes of hemiparesis. A single effective treatment for this condition is yet to be established; flunarizine is currently the most widely used but with varying degrees of success. An 18-month-old child presented with AHC and treatment with a combination of topiramate and flunarizine made a significant difference in controlling the frequency and severity of the attacks. This possibly allowed a better developmental outcome than in most children with this condition. Topiramate combined with flunarizine for treating AHC has much potential for further research.

Keywords: Alternating hemiplegia of childhood; flunarizine; topiramate

Document Type: Case Report

DOI: http://dx.doi.org/10.1179/1465328111Y.0000000007

Affiliations: Department of Paediatrics, National University Hospital, Singapore

Publication date: 2011-05-01

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