Severe pernicious anaemia in an 8-year-old African girl
Authors: van Loon, M.1; Postels, D.G.2; Heikens, G.T.1; Molyneux, E.1
Source: Annals of Tropical Paediatrics: International Child Health, Volume 29, Number 3, September 2009 , pp. 231-234(4)
Publisher: Maney Publishing
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Abstract:
An 8-year-old girl presented with severe muscular weakness, peripheral neuropathy, ataxia, fever and macrocytic anaemia. Clinically, vitamin B12 (cobalamin) deficiency was considered. Despite the lack of pre-treatment laboratory confirmation of the diagnosis, a therapeutic trial of hydroxocobalamin injections was begun. After several days, a partial clinical response was seen. Within 5 months all symptoms had resolved. After treatment was initiated, laboratory analysis of pre-treatment blood samples confirmed the presence of vitamin B12 deficiency. Auto-antibodies to intrinsic factor and parietal cells, pathognomonic for pernicious anaemia, were confirmed. Vitamin B12 deficiency owing to dietary deficiency is not uncommon in children in developing countries. Although nutritional deficiency might have played a role in our patient, this case illustrates that the neurological manifestations of pernicious anaemia can present at a young age in African populations.Document Type: Case report
DOI: 10.1179/027249309X12467994694094
Affiliations: 1: Department of Paediatrics & Child Health, College of Medicine, University of Malawi, Blantyre, Malawi 2: Presbyterian Medical Group, Albuquerque, New Mexico, USA
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