IngentaConnect Pattern of liver diseases in Oman

Authors: Al-Lawati, T.T.¹; George, M.¹; Al-Lawati, F.A.R.²

Source: Annals of Tropical Paediatrics: International Child Health, Volume 29, Number 3, September 2009 , pp. 183-189(7)

Publisher: Maney Publishing

Abstract:

Arab Gulf countries including Oman have a high rate of consanguineous marriage with an associated increased frequency of a variety of genetic disorders including liver diseases.

Aim: To describe the pattern of chronic liver diseases at The Royal Hospital, Muscat during the period January 2005 to January 2007.

Methods: A retrospective study of all children with chronic liver diseases seen at the Royal Hospital, which is a tertiary referral centre for gastro-enterology and hepatology for the whole of Oman.

Results: Seventy-nine patients with chronic liver disease were identified. The consanguinity rate amongst parents was 78%. The mean (SD) age of patients at the time of final diagnosis was 5 years (4). The two most common liver disorders were progressive familial intrahepatic cholestasis (30%) and fibrocystic disease of liver and kidney (21%). One-third of the patients came from the Sharqiya region. Complications included growth retardation (75%), cirrhosis (26%) and portal hypertension (39%). Three children died and three others received living related liver transplant.

Conclusion: About half of the chronic liver disorders in Oman are hereditary in origin. At least three children per year will require liver transplant.

Document Type: Research article

DOI: 10.1179/027249309X12467994693770

Affiliations: 1: Division of Child Health, Royal Hospital, Muscat, Sultanate of Oman 2: Department of Histopathology, Royal Hospital, Muscat, Sultanate of Oman

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