Authors: Dursun, Ismail¹; Gunduz, Zubeyde¹; Poyrazoglu, Hakan¹; Gumus, Hakan²; Yikilmaz, Ali¹; Dusunsel, Ruhan³

Source: Annals of Tropical Paediatrics: International Child Health, Volume 28, Number 2, June 2008 , pp. 155-159(5)

Publisher: Maney Publishing

Abstract:

Cerebral vasculitis associated with acute post-streptococcal glomerulonephritis (APSGN) is rare. A 13-year-old girl presented with severe headache, vomiting, oedema and macroscopic haematuria. There was a history of upper respiratory infection 2 weeks previously. A diagnosis of APSGN was made. On admission, she was normotensive and biochemically well balanced. She experienced a tonic-clonic seizure 2 hours later. An MRI brain scan demonstrated multiple areas of abnormal signal intensity in the cerebral and cerebellar white matter, and subarachnoid haemorrhage consistent with vasculitis was diagnosed. A sixth-nerve palsy developed on the 6th day of admission. An elevated anti-streptolysin titre and low serum C3 complement level together with typical features on renal biopsy supported the diagnosis of APSGN. All clinical and laboratory abnormalities improved with corticosteroid therapy, pulse methyl-prednisolone. APSGN can present with central nervous system abnormalities without hypertension, uraemia and electrolyte disturbance.

Document Type: Case Report

DOI: http://dx.doi.org/10.1179/146532808X302198

Affiliations: 1: Department of Paediatric Nephrology, Erciyes University, Kayseri, Turkey 2: Department of Neurology, Erciyes University, Kayseri, Turkey 3: Department of Radiology, Faculty of Medicine, Erciyes University, Kayseri, Turkey

Publication date: 2008-06-01

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• In 2012 Annals of Tropical Paediatrics changed its name to Paediatrics and International Child Health to reflect changes and developments in the subject area. View the issues of Paediatrics and International Child Health available online.
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