Incidental raised transaminases: a clue to muscle disease
Authors: Urganci, Nafiye1; Arapoğlu, Müjde1; Serdaroğlu, Piraye2; Nuhoğlu, Asiye2
Source: Annals of Tropical Paediatrics: International Child Health, Volume 26, Number 4, December 2006 , pp. 345-348(4)
Publisher: Maney Publishing
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Abstract:
Twenty-one patients with incidental hypertransaminasaemia who were eventually diagnosed as muscular dystrophy are described. There were two females and 19 males aged between 2 and 11 years [mean (SD) 6.7 (3.4) y]. Serum alanine and aspartate transaminase levels were between 73 and 595 IU/L (30-35) and 68 and 550 IU/L (30-35), respectively. Muscle disease was suspected when creatine phosphokinase levels were elevated and confirmed in each patient by muscle biopsy. The time interval between incidental hypertransaminasemia and the diagnosis of muscle disase was between 3 and 12 months. Eleven patients were diagnosed as Becker's muscle dystrophy, eight as Duchenne muscle dystrophy and two had sarcoglycanopathy. Long-term elevation of transaminase levels might be a sign of occult muscle disease. Invasive tests such as liver biopsy should not be performed in patients with unexplained hypertransaminasaemia without first determining creatinine phosphokinase levels.Document Type: Research article
DOI: 10.1179/146532806X152872
Affiliations: 1: Department of Clinical Pediatrics, Sisli Etfal Hospital, Istanbul, Turkey 2: Department of Neurology Faculty of Medicine, University of Istanbul, Istanbul, Turkey
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