@article {Tumgor:December 2006:0272-4936:285,
	author = "Tumgor, Gokhan",
	author = "Celik, Umit",
	author = "Alabaz, Derya",
	author = "Cetiner, Salih",
	author = "Yaman, Akgun",
	author = "Yildizdas, Dincer",
	author = "Alhan, Emre",
	title = "Aetiological agents, interleukin-6, interleukin-8 and CRP concentrations in children with community- and hospital-acquired pneumonia",
	journal = "Annals of Tropical Paediatrics: International Child Health",
	volume = "26",
	year = "December 2006",
	abstract = "<I>Objective</I>: To determine the pathogens causing pneumonia in community-acquired pneumonia (CAP) and hospital-acquired pneumonia (HAP) and to investigate serum levels of interleukin-6 (IL-6), interleukin-8 (IL-8) and CRP in pneumonia caused by different aetiological agents.<P></P><I>Study design</I>: Eighty-seven children (mostly &#60; 5 years of age) were recruited in a prospective study, 55 of them with CAP without prior antibiotic treatment and 32 with HAP. Thirty healthy outpatient children served as controls.<P></P><I>Results</I>: The causative micro-organisms were determined by serological and microbiological methods in 40 cases with CAP (72.7%) and 30 with HAP (93.7%). In CAP, <I>M. pneumoniae</I> was the most common causative agent (43.6%), followed by <I>S. pneumoniae</I> (20%) and <I>C. pneumoniae</I> (18.1%). Bacteria alone were the sole causative agents in only 21.8% of cases with HAP. <I>Pseudomonas aeruginosa</I> (34.3%) and <I>K. pneumoniae</I> (32.5%) were the most frequently isolated. Although IL-6 and IL-8 levels were raised, there was no statistical difference between the CAP and HAP groups, or between bacterial and mycoplasma infections; neither was there a difference in CRP levels between these two groups.<P></P><I>Conclusion</I>: The causes of pneumonia differ between CAP and HAP. Levels of IL-6, IL-8 and CRP are raised in pneumonia but are unhelpful in differentiating the various aetiologies.",
	pages = "285-291(7)",
	url = "http://www.ingentaconnect.com/content/maney/atp/2006/00000026/00000004/art00003"
	doi = "doi:10.1179/146532806X152809"
}