Clinical observation of meningitis caused by penicillin-susceptible and -non-susceptible Streptococcus pneumoniae in Taiwanese children
Authors: Chen, Shih-Hsiang1; Yen, Meng Hsiu1; Chiu, Cheng-Hsun2; Yan, Dah-Chin1; Hsu, Chih-Yi3; Lin, Tzou-Yien2
Source: Annals of Tropical Paediatrics: International Child Health, Volume 26, Number 3, September 2006 , pp. 181-185(5)
Publisher: Maney Publishing
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Abstract:
Aim: To compare differences between clinical features and outcome in bacterial meningitis caused by penicillin-susceptible Streptococcus pneumoniae (PSSP) with that caused by penicillin-non-susceptible Streptococcus pneumoniae (PNSP).Methods: All patients <18 yrs hospitalised with pneumococcal meningitis between January 1984 and December 2002 at Chang Gung Children's Hospital, Taipei were reviewed retrospectively.Results: There were 28 PNSP (63.6%) and 16 PSSP cases of meningitis eligible for the study. The incidence of PNSP meningitis increased significantly over the 8-yr period (p=0.007). Age <4 yrs (78.6% vs 50%), a lower initial white blood count (mean 11.7 vs 19.9 ×109/L), admission to the intensive care unit (70.4% vs 50%) and mortality (28.6% vs 6.3%) were more common in the PNSP group. However, the only significant finding was a lower proportion of polymorphic neutrophils in the CSF of the PNSP meningitis group (p=0.04).Conclusions: There was an increase in PNSP isolates from patients with meningitis over the 8-yr study period. No major differences were observed in clinical or laboratory features or outcome between the PSSP and PNSP groups.Document Type: Research article
DOI: 10.1179/146532806X120264
Affiliations: 1: Division of Pediatrics, Chang Gung Children's Hospital, Taipei, Taiwan, Republic of China 2: Division of Pediatric Infectious Diseases, Chang Gung Children's Hospital, Taipei, Taiwan, Republic of China 3: Departments of Pathology & Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China; Department of Pathology, National Yang-Ming University School of Medicine, Taipei, Taiwan, Republic of China
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