Authors: Chen, Shih-Hsiang¹; Yen, Meng Hsiu¹; Chiu, Cheng-Hsun²; Yan, Dah-Chin¹; Hsu, Chih-Yi³; Lin, Tzou-Yien²

Source: Annals of Tropical Paediatrics: International Child Health, Volume 26, Number 3, September 2006 , pp. 181-185(5)

Publisher: Maney Publishing

Abstract:

Aim: To compare differences between clinical features and outcome in bacterial meningitis caused by penicillin-susceptible Streptococcus pneumoniae (PSSP) with that caused by penicillin-non-susceptible Streptococcus pneumoniae (PNSP).

Methods: All patients <18 yrs hospitalised with pneumococcal meningitis between January 1984 and December 2002 at Chang Gung Children's Hospital, Taipei were reviewed retrospectively.

Results: There were 28 PNSP (63.6%) and 16 PSSP cases of meningitis eligible for the study. The incidence of PNSP meningitis increased significantly over the 8-yr period (p=0.007). Age <4 yrs (78.6% vs 50%), a lower initial white blood count (mean 11.7 vs 19.9 ×10⁹/L), admission to the intensive care unit (70.4% vs 50%) and mortality (28.6% vs 6.3%) were more common in the PNSP group. However, the only significant finding was a lower proportion of polymorphic neutrophils in the CSF of the PNSP meningitis group (p=0.04).

Conclusions: There was an increase in PNSP isolates from patients with meningitis over the 8-yr study period. No major differences were observed in clinical or laboratory features or outcome between the PSSP and PNSP groups.

Document Type: Research Article

DOI: http://dx.doi.org/10.1179/146532806X120264

Affiliations: 1: Division of Pediatrics, Chang Gung Children's Hospital, Taipei, Taiwan, Republic of China 2: Division of Pediatric Infectious Diseases, Chang Gung Children's Hospital, Taipei, Taiwan, Republic of China 3: Departments of Pathology & Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China; Department of Pathology, National Yang-Ming University School of Medicine, Taipei, Taiwan, Republic of China

Publication date: 2006-09-01

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• In 2012 Annals of Tropical Paediatrics changed its name to Paediatrics and International Child Health to reflect changes and developments in the subject area. View the issues of Paediatrics and International Child Health available online.
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