IngentaConnect Haematological abnormalities associated with paediatric HIV/AIDS ...

Authors: Adetifa, I.M.O.¹; Temiye, E.O.¹; Akinsulie, A.O.¹; Ezeaka, V.C.¹; Iroha, E.O.¹

Source: Annals of Tropical Paediatrics: International Child Health, Volume 26, Number 2, June 2006 , pp. 121-125(5)

Abstract:

Introduction: In HIV-1-infected children, haematological disturbances include bone marrow abnormalities and peripheral cytopenias. All three major cell lineages can be depressed.

Methods: A cross-sectional study of baseline haematological parameters was undertaken in 68 children with confirmed HIV infection. In all cases, a complete blood count was done and some had CD4+ counts and HIV RNA PCR. The CD4+ count was analysed by the Coulter manual latex particle monoclonal antibody method^® and HIV RNA PCR by Roche^© Amplicor Monitor, version 1.5.

Results: Anaemia (<100 g/L) was present in 77.9%, severe (<60 g/L) in 5.9%, moderate (60–70 g/L) in 32.3% and mild (80–99 g/L) in 39.7%. The mean haemoglobin concentration decreased as disease progressed (p<0.05); 6% had leucopenia, 17.5% had neutropenia and 2.5% (one case) had thrombocytopenia; also, the four (6%) subjects with leucopenia were in clinical stages B and C. Neutropenia, lymphocytopenia and thrombocytopenia were seen more in clinical stages B and C, though this relationship was not statistically significant.

Conclusion: Both the erythroid and other cells lines are affected by HIV/AIDS and other associated factors. Anaemia is the most common haematological abnormality. The severity of peripheral cytopenias is related to the disease burden.

Document Type: Research article

DOI: 10.1179/146532806X107467

Affiliations: 1: Department of Paediatrics, Lagos University Teaching Hospital, Lagos, Nigeria

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$51.00 plus tax Refund Policy

Haematological abnormalities associated with paediatric HIV/AIDS in Lagos