Authors: Taha, Taha¹; Kumwenda, Newton¹; Kafulafula, George²; Kumwenda, Johnstone³; Chitale, Rohit¹; Nkhoma, Chiwawa⁴; Katundu, Pauline⁴; Mukiibi, Joshua⁵; Chen, Shu¹; Hoover, Donald⁶; Broadhead, Robin⁷

Source: Annals of Tropical Paediatrics: International Child Health, Volume 24, Number 4, December 2004 , pp. 301-309(9)

Publisher: Maney Publishing

Abstract:

We assessed the safety of short-term antiretroviral prophylaxis to prevent mother-to-child transmission (MTCT) of HIV by monitoring haematological changes in children up to the age of 18 months. Babies of HIV-infected women were randomised at birth to receive a single dose of nevirapine (NVP) alone or with zidovudine (ZDV) twice daily for a week. Based on the time of presentation to the labour ward, mothers of these babies might or might not have received intrapartum NVP. Complete blood counts were performed at birth and at 1.5, 3, 6, 9, 12, 15 and 18 months. Babies' HIV status was determined by HIV-1 RNA testing. A total of 1755 babies were included in the study. Age-specific mean haemoglobin levels and prevalence of anaemia (haemoglobin < 10 g/dL) were not significantly different in cases where only the babies received a single dose of NVP and cases where NVP was given to mother/infant pairs or additional ZDV to the baby. Among HIV-infected children compared with uninfected children, the age-specific frequency of anaemia was significantly greater, anaemia started earlier and recovery to normal levels was slower and prolonged. A reversible granulocytopenia was observed in all children between 1.5 and 3 months of age. HIV infection significantly increased the children's risk of death. Antiretroviral prophylaxis appeared to protect against anaemia and child death. Short regimens of antiretrovirals to prevent MTCT of HIV are not associated with long-term adverse haematological changes.

Document Type: Research Article

DOI: http://dx.doi.org/10.1179/027249304225019127

Affiliations: 1: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA 2: Department of Obstetrics & Gynaecology, University of Malawi College of Medicine, Malawi 3: Department of Medicine, University of Malawi College of Medicine, Malawi 4: Johns Hopkins University–Malawi College of Medicine Research Project, Blantyre, Malawi 5: Department of Haematology, University of Malawi College of Medicine, Malawi 6: Department of Statistics and Institute for Health, Health Care Policy & Aging Research, Rutgers University, NJ, USA 7: Department of Paediatrics, University of Malawi College of Medicine, Malawi

Publication date: 2004-12-01

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• In 2012 Annals of Tropical Paediatrics changed its name to Paediatrics and International Child Health to reflect changes and developments in the subject area. View the issues of Paediatrics and International Child Health available online.
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• By this author: Taha, Taha ;  Kumwenda, Newton ;  Kafulafula, George ;  Kumwenda, Johnstone ;  Chitale, Rohit ;  Nkhoma, Chiwawa ;  Katundu, Pauline ;  Mukiibi, Joshua ;  Chen, Shu ;  Hoover, Donald ;  Broadhead, Robin

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