@article {van Rheenen:2004-03-01T00:00:00:0272-4936:3,
	author = "van Rheenen, Patrick and Brabin, Bernard J.",
	title = "Late umbilical cord-clamping as an intervention for reducing iron deficiency anaemia in term infants in developing and industrialised countries: a systematic review",
	journal = "Annals of Tropical Paediatrics: International Child Health",
	volume = "24",
	number = "1",
	year = "2004-03-01T00:00:00",
	abstract = "This review evaluates the potential of delayed cord-clamping for improving iron status and reducing anaemia in term infants and for increasing the risk of polycythaemia and hyperbilirubinaemia. We applied a strict search protocol to identify controlled trials of early <i xmlns="http://pub2web.metastore.ingenta.com/ns/">vs</i> late cord-clamping. Four trials from developing and four from industrialised countries were finally assessed. Two of the four studies from developing countries found a significant difference in infant haemoglobin levels at 2-3 months of age in favour of delayed cord-clamping. This difference was more marked when mothers were anaemic. Three of four studies from industrialised countries showed a significant difference in haematocrit levels in favour of delayed clamping. Although meta-analysis showed an increased risk for hyperbilirubinaemia of 12%, no studies reported the need to apply phototherapy or perform exchange transfusion. We conclude that delayed cord-clamping in term infants, especially those with anaemic mothers, increases haemoglobin concentration in infants at 2-3 months of age and reduces the risk of anaemia, without an associated increased risk of perinatal complications. In developing countries where fetal anaemia is common, the advantages of delayed cord-clamping might be especially beneficial.",
	pages = "3-16",
	url = "http://www.ingentaconnect.com/content/maney/atp/2004/00000024/00000001/art00001",
	doi = "doi:10.1179/027249304225013286",
	keyword = ""
}