Authors: Tantangmo, F.¹; Lenta, B. N.²; Boyom, F. F.³; Ngouela, S.¹; Kaiser, M.⁴; Tsamo, E.¹; Weniger, B.⁵; Rosenthal, P. J.⁶; Vonthron-Sénécheau, C.⁷

Source: Annals of Tropical Medicine and Parasitology, Volume 104, Number 5, July 2010 , pp. 391-398(8)

Publisher: Maney Publishing

Abstract:

Phytochemical investigation of an ethyl-acetate extract of the stem bark of Markhamia tomentosa (Bignoniaceae), which had good antimalarial activity in vitro, resulted in the isolation of eight known compounds: 2-acetylnaphtho[2,3-b]furan-4,9-dione (1), 2-acetyl-6-methoxynaphtho[2,3-b]furan-4,9-dione (2), oleanolic acid (3), pomolic acid (4), 3-acetylpomolic acid (5), tormentic acid (6), β-sitosterol (7) and β-sitosterol-3-O-β-D-glucopyranoside (8). The structures of these compounds were established by spectroscopic methods. Each of compounds 1, 2, 4 and 5 was evaluated in vitro for its antiprotozoal activities against the ring stages of two chloroquine-resistant strains of Plasmodium falciparum (K1 and W2), the amastigotes of Leishmania donovani, and the bloodstream trypomastigotes of Trypanosoma brucei rhodesiense (the species responsible for human malaria, visceral leishmaniasis and African trypanosomiasis, respectively). Although compounds 1 and 2 exhibited potent antiprotozoal activities, they also showed high toxicity against a mammalian (L-6) cell line.

Document Type: Research Article

DOI: http://dx.doi.org/10.1179/136485910X12743554760180

Affiliations: 1: Department of Organic Chemistry, Faculty of Science, TWAS Research Unit of the University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon 2: Department of Chemistry, Higher Teachers' Training College, University of Yaoundé I, P.O. Box 47, Yaoundé, Cameroon 3: Department of Biochemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon 4: Swiss Tropical and Public Health Institution, Socinstrasse 57, CH-4002 Basel, Switzerland 5: Laboratoire de Pharmacognosie et Molécules Naturelles Bioactives, UMR 7200, Faculté de Pharmacie, Université de Strasbourg, B.P. 60024, 67401, Illkirch Cedex, France 6: Division of Infectious Diseases, Department of Medicine, University of California, San Francisco, 1001 Portero Avenue, San Francisco, CA 94943, U.S.A. 7: Laboratoire de Pharmacognosie et Molécules Naturelles Bioactives, UMR 7200, Faculté de Pharmacie, Université de Strasbourg, B.P. 60024, 67401, Illkirch Cedex, France, Laboratoire de Biologie et de Biotechnologies Marines, UMR M IFREMER 100, Université de Caen Basse-Normandie, Esplanade de la Paix, 14032 Caen Cedex, France; Email: vonthron@unistra.fr

Publication date: 2010-07-01

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• In 2012 Annals of Tropical Medicine and Parasitology changed its name to Pathogens of Global Health to reflect changes and developments in the subject area. View the issues of Pathogens of Global Health available online..
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