IngentaConnect Mirazid shows insignificant activity against ovine fascioliasis

Authors: Botros, S.S.¹; El-Lakkany, N.M.¹; Badawy, A.A.²; Mahmoud, S.S.³; Ebeid, F.A.¹; Fenwick, A.⁴

Source: Annals of Tropical Medicine and Parasitology, Volume 103, Number 7, October 2009 , pp. 605-616(12)

Abstract:

In a recent study, the fasciolicidal activity of Mirazid (a myrrh-derived drug) and its effect on the function and histopathology of host liver were investigated in Egyptian sheep, with triclabendazole (TCBZ) used as the positive control. Sheep were infected with metacercariae (150/animal) and treated 3 months later, either with Mirazid (10 mg/kg/day for six consecutive days) or TCBZ (a single dose of 10 mg/kg), or left untreated, as controls. When the animals were killed 4 weeks after the end of treatment, no Fasciola flukes or eggs could be found in the animals given TCBZ but the number of flukes found in the Mirazid-treated animals was only 6% lower than that recorded in the untreated sheep (a statistically insignificant difference). In terms of their Fasciola egg loads, serum concentrations of hepatic enzymes and hepatic histopathological changes, the Mirazid-treated sheep appeared very similar to the untreated, infected animals. The TCBZ-treated animals, in contrast, showed remarkably little evidence of hepatic pathology. It therefore appears that, in the treatment of ovine fascioliasis, at least some batches of Mirazid have little, if any, value.

Document Type: Research article

DOI: 10.1179/000349809X12459740922453

Affiliations: 1: Pharmacology Department, Theodor Bilharz Research Institute, 1 El-Nile Street, Warrak El-Hadar, P.O. Box 30, Imbaba, 12411, Giza, Egypt 2: Pathology Department, Theodor Bilharz Research Institute, 1 El-Nile Street, Warrak El-Hadar, P.O. Box 30, Imbaba, 12411, Giza, Egypt 3: Parasitology Department, Theodor Bilharz Research Institute, 1 El-Nile Street, Warrak El-Hadar, P.O. Box 30, Imbaba, 12411, Giza, Egypt 4: Department of Infectious Disease Epidemiology, Imperial College, St. Mary's Campus, Norfolk Place, London W2 1PG, U.K.

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