Authors: Adam, I.¹; Elhardello, O. A.²; Elhadi, M. O.³; Abdalla, E.²; Elmardi, K. A.⁴; Jansen, F. H.⁵

Source: Annals of Tropical Medicine and Parasitology, Volume 102, Number 1, January 2008 , pp. 39-44(6)

Publisher: Maney Publishing

Abstract:

Although artemisinin and its derivatives are widely used for the treatment of malaria, they also have antischistosomal activity. In a small study in eastern Sudan, the effects of the treatment of uncomplicated, Plasmodium falciparum malaria with artesunate–sulfamethoxypyrazine–pyrimethamine (AS–SMP) and artemether–lumefantrine (AT–LU) on co-infections with Schistosoma mansoni were therefore investigated. Faecal samples from 14 of the 306 patients screened on presentation, at the start of a clinical trial of antimalarial treatment, were found to contain Schistosoma mansoni eggs. For the treatment of their malaria, the 14 egg-positive cases, who were aged 6–40 years (mean = 13.7 years), were each subsequently treated with three tablets of a fixed combination of AS–SMP, with a 12-h (six patients) or 24-h interval (five patients) between each tablet, or with six doses of AT–LU given over 3 days. When checked 28 and 29 days after the initiation of treatment, all 14 patients were found stool-negative for schistosome eggs. These results indicate that AS–SMP and AT–LU are currently very effective treatments not only for uncomplicated, P. falciparum malaria but also for S. mansoni infections.

References: 13 references open in new window

Articles that cite this article?

Document Type: Research Article

DOI: http://dx.doi.org/10.1179/136485908X252214

Affiliations: 1: Faculty of Medicine, University of Khartoum, P.O. Box 102, Khartoum, Sudan 2: New Halfa Teaching Hospital, P.O. Box 68, New Halfa, Sudan 3: National Center for Research, P.O. Box 2404, Khartoum, Sudan 4: National Malaria Control Programme, Ministry of Health, P.O. Box 1204, Khartoum, Sudan 5: Dafra Pharma NV, Slachthuisstrat 30/7, 2300 Turnhout, Belgium

Publication date: 2008-01-01

More about this publication?

• In 2012 Annals of Tropical Medicine and Parasitology changed its name to Pathogens and Global Health to reflect changes and developments in the subject area. View the issues of Pathogens and Global Health available online..
• Editorial Board
• Information for Authors
• Submit a Paper
• Subscribe to this Title
• Information for Advertisers
• Terms & Conditions
• Top articles
• Health Sciences Spotlight
• Abstracted in
• ingentaconnect is not responsible for the content or availability of external websites

Related content

• In this: publication
• By this: publisher
• In this Subject: Internal Medicine
• By this author: Adam, I. ;  Elhardello, O. A. ;  Elhadi, M. O. ;  Abdalla, E. ;  Elmardi, K. A. ;  Jansen, F. H.

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers