Zoonotic species of Cryptosporidium are as prevalent as the anthroponotic in HIV-infected patients in Thailand

Authors: Gatei W.1; Suputtamongkol Y.2; Waywa D.2; Ashford R.W.3; Bailey J.W.3; Greensill J.2; Beeching N.J.3; Hart C.A.4

Source: Annals of Tropical Medicine and Parasitology, Volume 96, Number 8, December 2002 , pp. 797-802(6)

Publisher: Maney Publishing

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Abstract:

The epidemiology of chronic diarrhoea in adults with late-stage HIV infection was investigated in a prospective study in Bangkok, Thailand. During this investigation, 34 Cryptosporidium isolates were obtained from the faeces of 36 patients, with mean CD4+ counts of only 14 × 106 CD4+ cells/litre (range = 2 × 106 - 53 × 106/litre), who had symptomatic cryptosporidiosis. Genotyping of these isolates, by RFLP analysis and DNA sequencing of the hypervariable region of the 18S rRNA gene, indicated that only 17 (50%) were of the C. parvum human genotype. The rest were of C. meleagridis (seven), the C. parvum 'bovine' genotype (five), C. felis (three) and C. canis (two). Extensive genotypic heterogeneity was observed among the C. parvum isolates, and two other isolates, one of C. meleagridis and the other of C. felis, produced atypical restriction patterns and were only identified by sequencing. This appears to represent the first report of C. canis and the 'bovine' genotype of C. parvum in HIV-infected Thai patients.

Document Type: Original article

DOI: 10.1179/000349802125002202

Affiliations: 1: Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, U.K.; Department of Medical Microbiology and Genito-Urinary Medicine, University of Liverpool, Daulby Street, Liverpool, L69 3GA, U.K. 2: Department of Medicine, Faculty of Medicine at Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand 3: Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, U.K. 4: Department of Medical Microbiology and Genito-Urinary Medicine, University of Liverpool, Daulby Street, Liverpool, L69 3GA, U.K.

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