Taxol: Synthesis, Bioactive Conformations, and Structure-Activity Relationships in Its Analogs

Authors: Zefirova, O.¹; Nurieva, E.²; Ryzhov, A.³; Zyk, N.²; Zefirov, N.²

Source: Russian Journal of Organic Chemistry, Volume 41, Number 3, March 2005 , pp. 315-351(37)

Publisher: MAIK Nauka/Interperiodica

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Abstract:

The review describes the syntheses and probable biologically active conformations of taxol, a natural antitumor agent, and systematizes published data on the structure-activity relations in the series of taxol analogs.

Document Type: Research article

DOI: http://dx.doi.org/10.1007/s11178-005-0168-0

Affiliations: 1: Faculty of Chemistry, Lomonosov Moscow State University, Vorob’evy gory 1, Moscow, 119992, Russia, Email: olgaz@org.chem.msu.ru 2: Faculty of Chemistry, Lomonosov Moscow State University, Vorob’evy gory 1, Moscow, 119992, Russia, 3: Zelinskii Institute of Organic Chemistry, Russian Academy of Sciences, Leninskii pr. 47, Moscow, 117913, Russia,

Publication date: 2005-03-01