Authors: Mikhaylenko, D.¹; Lyubchenko, L.²; Zborovskaya, I.³; Strelnikov, V.⁴; Zaletayev, D.⁵

Source: Russian Journal of Genetics, Volume 41, Number 9, September 2005 , pp. 1059-1062(4)

Publisher: MAIK Nauka/Interperiodica

Abstract:

The GIPC1 gene product promotes clustering of some transmembrane receptors, including those involved in carcinogenesis, and protects them against ubiquitin-dependent degradation. The 5′ untranslated region of GIPC1 contains a polymorphic trinucleotide CGG repeat, which has not been characterized earlier. In the present study, we have carried out comparative analysis of the allele and genotype frequencies of this repeat in 129 samples of breast cancer (BC), 58 samples of non-small cell lung cancer (NSCLC), and 215 samples of healthy donors. The CGG repeat in the 5′ untranslated GIPC1 gene region was shown to be highly polymorphic and represented by at least eight alleles. Alleles CGG _10–13 were major, occurring at frequencies of 22, 41, 27, and 9%, respectively; the total frequency of the remaining alleles was approximately 1%. Heterozygosity of the CGG repeat was 0.70. Allele CGG ₁₂ was shown to be associated with high risk of developing NSCLC (α = 0.05).

Document Type: Research article

DOI: http://dx.doi.org/10.1007/s11177-005-0200-z

Affiliations: 1: Research Center for Medical Genetics, Russian Academy of Medical Sciences, Moscow, 115478, Russia, Email: dimserg@mail.ru, zalnem@online.ru 2: Blokhin Research Center for Oncology, Russian Academy of Medical Sciences, Moscow, 115478, Russia, 3: Institute of Carcinogenesis, Blokhin Research Center for Oncology, Russian Academy of Medical Sciences, Moscow, 115478, Russia, 4: Research Center for Medical Genetics, Russian Academy of Medical Sciences, Moscow, 115478, Russia, 5: Research Center for Medical Genetics, Russian Academy of Medical Sciences, Moscow, 115478, Russia, Email: aavianov@mmascience.ru

Publication date: 2005-09-01

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