Genomic dosages of active rRNA genes in coke-oven workers

Authors: Minina, V.¹; Druzhinin, V.²

Source: Russian Journal of Genetics, Volume 40, Number 12, December 2004 , pp. 1413-1418(6)

Publisher: MAIK Nauka/Interperiodica

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Abstract:

Genomic dosage (copy number) of active ribosomal genes was evaluated using visual semi-quantitative method determining the sizes of Ag-NORs in acrocentric chromosomes after selective silver nitrate staining. A relationship between the length of service and the active ribosomal gene copy number was established: the highest numbers of active rRNA genes were observed in coke-oven workers with a length of service exceeding 20 years. An inverse relationship between the individual doses of active ribosomal genes and toxicogenetic susceptibility of the workers to the occupational factors was also revealed.

Document Type: Research article

DOI: http://dx.doi.org/10.1007/s11177-005-0074-0

Affiliations: 1: Department of Genetics, Kemerovo State University, 650043, Kemerovo, Russia, Email: vminina@mail.ru 2: Department of Genetics, Kemerovo State University, 650043, Kemerovo, Russia, Email: druzhinin_vladim@mail.ru

Publication date: 2004-12-01