IngentaConnect The Genotoxic Effect of the New Acaricide Etoxazole

Authors: E. Rencüzog breve ullari¹; H. Basri Idot la¹; A. Kayraldiz²; M. Arslan²; S. Budak Diler²; M. Topaktas¸¹

Source: Russian Journal of Genetics, Volume 40, Number 11, November 2004 , pp. 1300-1304(5)

Publisher: MAIK Nauka/Interperiodica

Abstract:

Etoxazole is a member of the diphenyl oxazoline class of insecticide, which was newly developed for use on pome fruits, cotton and strawberries as an acaricide. In the present study, genotoxic effects of acaricide etoxazole (ETX) (miticide/ovicide) were investigated using chromosome aberration (CA) test, sister chromatid exchange (SCE) test, and micronucleus test in human lymphocytes. ETX induced the CAs at all concentrations (5, 10, and 20

g/ml) for 24 h and also induced the CA at the highest concentration (20

g/ml) for 48 h only. The inducing the CAs for 48 h treatment period was dose-dependent. In addition, it induced the SCE at all concentrations and treatment periods in a dose-dependent manner as well. Although ETX decreased the mitotic index (MI) at all concentrations and treatment periods dose-dependently, it did not decrease the replication index (RI) when compared to the negative and solvent controls. In addition, ETX induced the micronucleus at all concentrations except 5

g/ml for 48 h. This inducing was dose-dependent as well. It can be concluded that ETX has a potential genotoxic effects in cultured human peripheral lymphocytes.

Document Type: Research article

DOI: 10.1023/B:RUGE.0000048674.00728.2f

Affiliations: 1: Cukurova University, Faculty of Arts and Sciences, Department of Biology, Adana, 01330 Turkey reyyup@mail.cu.edu.tr, Email: reyyup@mail.cu.edu.tr 2: Cukurova University, Natural and Applied Sciences Institute, Biology Department, Adana, 01330 Turkey

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