IngentaConnect Restriction Polymorphism of Mitochondrial DNA in Koreans and Mong...

Authors: M. V. Derenko¹; A. V. Lunkina¹; B. A. Malyarchuk¹; I. A. Zakharov²; Ts. Tsedev³; K. S. Park⁴; Y. M. Cho⁴; H. K. Lee⁴; Ch. H. Chu⁵

Source: Russian Journal of Genetics, Volume 40, Number 11, November 2004 , pp. 1292-1299(8)

Publisher: MAIK Nauka/Interperiodica

Abstract:

Using the data on mitochondrial DNA (mtDNA) restriction polymorphism, the gene pools of Koreans (N = 164) and Mongolians (N = 48) were characterized. It was demonstrated that the gene pools were represented by the common set of mtDNA haplogroups of East Asian origin (M*, M7, M8a, M10, C, D4, G*, G2, A, B*, B5, F1, and N*). In addition to this set, mtDNA haplogroups D5 and Y were identified in Koreans while Mongolians possessed haplogroup Z. Only in Mongolians, a European component with the frequency of 10.4% and represented by the mtDNA types belonging to haplogroups K, U4, and N1, was identified. Phylogenetic and statistical analyses of the data on mtDNA variation in the populations of South Siberia, Central, and East Asia suggested the existence of interpopulation differentiation within these regions, the main role in which was played by the geographical and linguistic factors. Analysis of the pairwise F_ST distances demonstrated close genetic similarity of Koreans to Northern Chinese, which in turn, were clearly different from Southern Chinese populations. Mongolians occupied an intermediate position between the ethnic groups of South Siberia and Central/East Asia.

Document Type: Research article

DOI: 10.1023/B:RUGE.0000048673.70713.a5

Affiliations: 1: Institute of the Biological Problems of the North, Russian Academy of Sciences, Magadan, 685000 Russia mderenko@ibpn.kolyma.ru, Email: mderenko@ibpn.kolyma.ru 2: Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, 119991 Russia 3: Institute of Biological Sciences, Mongolian Academy of Sciences, Ulanbatar, 510351 Mongolia 4: Seoul National University, College of Medicine, Seoul, 151-742 Korea 5: Department of History, Kangwon National University, Chunchon, 200-701 Korea

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Restriction Polymorphism of Mitochondrial DNA in Koreans and Mongolians