Allele Distribution at the HVR-IgH Hypervariable Locus in Unrelated Individuals Living in the Urals, Siberia, and Northern Kazakhstan

Authors: Bin'ko I.A.¹; Shorokhova D.A.¹; Schwartz Y.B.²; Demakov S.A.²; Novoselov V.P.¹

Source: Russian Journal of Genetics, Volume 38, Number 4, April 2002 , pp. 429-433(5)

Publisher: MAIK Nauka/Interperiodica

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Abstract:

Allelic polymorphism at a hypervariable locus mapped to the 5"-region of the gene cluster encoding J_H segments of human immunoglobulin heavy chain H (IgH-VNTR) was typed in 462 unrelated individuals living in the Urals, Siberia, and Northern Kazakhstan. Molecular characteristics of the three previously unknown IgH-VNTR alleles are presented. The observed genotype frequencies were concordant with those expected under the Hardy–Weinberg distribution. The data obtained can be used in the work of regional forensic laboratories.

Language: English

Document Type: Regular paper

Affiliations: 1: Regional Forensic Bureau, Novosibirsk, 630087 Russia sme@sme.nsk.su 2: Regional Forensic Bureau, Novosibirsk, 630087 Russia sme@sme.nsk.su. Institute of Cytology and Genetics, Russian Academy of Sciences, Novosibirsk, 630090 Russia yschwart@hgmp.mrc.ac.ru

Publication date: 2002-04-01