Study of the Association between Constitutional Exogenous Obesity and Polymorphism of the Apolipoprotein B Gene

Authors: Yatsyshina S.B.¹; Moliaka Y.K.²; Karpova S.K.³; Chekhranova M.K.³; Popova Y.P.⁴; Grigoryan O.N.⁴; Pankov Y.A.³; Rogaev E.I.⁵

Source: Russian Journal of Genetics, Volume 38, Number 2, February 2002 , pp. 220-222(3)

Publisher: MAIK Nauka/Interperiodica

Abstract:

An attempt was made to associate the insertion–deletion (Ins/Del) polymorphism of the apolipoprotein B gene (apoB) with obesity and to identify alleles and genotypes predisposing to this disorder. The apoB Ins/Del allele frequencies observed in the Russian population were similar to those in West European populations and significantly differed from frequencies reported for Asian populations. Patients with obesity did not differ from healthy individuals in allele and genotype frequencies regardless of whether total or sex-stratified samples were compared. Estimation of relative risk for individuals with genotype Ins/Ins did not reveal a significant association between obesity and this genotype. Thus, constitutional exogenous obesity did not prove to be associated with the Ins/Del polymorphism of the apoB gene in the Russian population.

Language: English

Document Type: Regular paper

Affiliations: 1: Endocrinology Research Center, Russian Academy of Medical Sciences, Moscow, 117036 Russia yuri-pankov@mtu-net.ru. Mental Health Research Center, Russian Academy of Medical Sciences, Moscow, 113152 Russia rogaev@dol.ru 2: Mental Health Research Center, Russian Academy of Medical Sciences, Moscow, 113152 Russia rogaev@dol.ru. Department of Medical Genetics, Sechenov Medical Academy, Moscow, 119881 Russia 3: Endocrinology Research Center, Russian Academy of Medical Sciences, Moscow, 117036 Russia yuri-pankov@mtu-net.ru 4: Institute of Nutrition, Russian Academy of Medical Sciences, Moscow, 109240 Russia 5: Mental Health Research Center, Russian Academy of Medical Sciences, Moscow, 113152 Russia rogaev@dol.ru

Publication date: 2002-02-01

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• In this Subject: Genetics
• By this author: Yatsyshina S.B. ;  Moliaka Y.K. ;  Karpova S.K. ;  Chekhranova M.K. ;  Popova Y.P. ;  Grigoryan O.N. ;  Pankov Y.A. ;  Rogaev E.I.

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