Genetic Differentiation of the Tuva Population with Respect to the AluInsertions

Authors: Stepanov V.A.¹; Khitrinskaya I.Y.²; Puzyrev V.P.³

Source: Russian Journal of Genetics, Volume 37, Number 4, April 2001 , pp. 453-459(7)

Publisher: MAIK Nauka/Interperiodica

Abstract:

Polymorphism of three rural populations of the Tuva Republic was examined using a set of five autosomal Aluinsertions at the ACE, PLAT,PV92, APOA1,and F13Bloci. The allele frequency distribution patterns revealed in Tuvinians were typical to Mongoloid populations of Asia and were characterized by relatively high frequency of the Alu-repeat insertion at the PV92and F13B loci along with relatively low insertion frequency at the APOA1locus. With respect to the test systems used, Tuvinian populations examined displayed high levels of genetic diversity. The mean expected heterozygosity values in the populations of Kungurtug, Toora-Khem, and Teeli were 0.433, 0.407, and 0.437, respectively. The level of genetic diversity in the pooled Tuvinian sample was 0.432. The coefficient of genetic differentiation in the three populations studied was 1.4% pointing to relatively low level of genetic subdivision of the indigenous Tuvinian populations. However, estimates of genetic differentiation of the Tuvinian gene pool made by use of the Alu-repeat system were higher compared to those performed using classical protein systems, mtDNA, or Y-chromosomal haplotypes. Even though Tuvinian populations were characterized by common gene pool, some features specific to Western Tuvinian population could be distinguished. These features could be associated with higher contribution of the Caucasian component to the gene pool of this population. Phylogenetic analysis demonstrated close genetic relationships between the Tuvinian and Altaic ethnic populations.

Language: English

Document Type: Regular paper

Affiliations: 1: Institute of Medical Genetics, Tomsk Research Center, Russian Academy of Medical Sciences, Tomsk 634050, Russia vadimst@img.tsu.ru. Tomsk State University, Tomsk, 634050 Russia. Siberian Medical University, Tomsk, 634050 Russia 2: Institute of Medical Genetics, Tomsk Research Center, Russian Academy of Medical Sciences, Tomsk 634050, Russia vadimst@img.tsu.ru 3: Institute of Medical Genetics, Tomsk Research Center, Russian Academy of Medical Sciences, Tomsk 634050, Russia vadimst@img.tsu.ru. Siberian Medical University, Tomsk, 634050 Russia

Publication date: 2001-04-01

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• By this author: Stepanov V.A. ;  Khitrinskaya I.Y. ;  Puzyrev V.P.

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