The Database for Analysis of Quantitative Characteristics of Chromosome Aberration Frequencies in the Culture of Human Peripheral Blood Lymphocytes
Authors: Bochkov N.P.1; Chebotarev A.N.1; Katosova L.D.1; Platonova V.I.1
Source: Russian Journal of Genetics, Volume 37, Number 4, April 2001 , pp. 440-447(8)
Publisher: MAIK Nauka/Interperiodica
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Abstract:
The data on spontaneous chromosome aberration rates in cultures of human peripheral blood lymphocytes obtained in the past 30 years have been collected to form a database. The database contains the results of analysis of more than 330 000 metaphases in lymphocytes from more than 1200 subjects. The frequency of aberrant metaphases in the control group has been estimated at 0.0213 ± 0.00085. No differences between sexes have been found with respect to either the total chromosome aberration rate or the rates of individual aberration types. The total chromosome aberration rate did not depend on age; however, it has been found that the number of fragments increased and the number of exchanges decreased with age. Smoking has been found to increase the frequency of chromosome aberrations in individuals with occupational hazards, but not in those who are not occupationally exposed to radiation or chemicals. Alcohol consumption increased the frequency of paired fragments, whereas the frequencies of other aberrations did not differ from the control values.
Language: English
Document Type: Regular paper
Affiliations: 1: Research Center for Medical Genetics, Russian Academy of Medical Sciences, Moscow, 115478 Russia
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