Serotonin Type 2a (5-HTR2A) Receptor Gene Polymorphism and Personality Traits in Patients with Major Psychoses

Authors: Golimbet V.E.1; Alfimova M.V.1; Manandyan K.K.1; Mitushina N.G.1; Abramova L.I.1; Kaleda V.G.1; Oleichik I.V.1; Yurov Y.B.1; Trubnikov V.I.1

Source: Russian Journal of Genetics, Volume 37, Number 4, April 2001 , pp. 436-439(4)

Publisher: MAIK Nauka/Interperiodica

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Abstract:

Genetic polymorphism of the serotonin receptor (5-HTR2A) gene has been reported to be associated with the expression of clinical traits characteristic of major psychoses, including schizophrenia and affective disorders. In this study, personality traits of patients with these diseases and the associations of these traits with 5-HTR2A allelic polymorphisms were studied. It was demonstrated that schizophrenic and affective patients with the 2/2genotype of serotonin receptor had lower scores on the anxiety scale and on the anxiety-related hypochondriasis and neuroticism scales than subjects with the 1/1and 1/2genotypes.

Language: English

Document Type: Regular paper

Affiliations: 1: Research Center for Mental Health, Russian Academy of Medical Sciences, Moscow, 113152 Russia trubnik@rcmh.msk.ru

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