Synthesis and Steric Structure of H-Leu-His-Lys-Leu-Gln-Thr-NH2 and H-Ala-D-Ala-Lys-Leu-Ala-Thr-NH2 Peptides
Source: Russian Journal of General Chemistry, Volume 75, Number 5, May 2005 , pp. 815-824(10)
Publisher: MAIK Nauka/Interperiodica
Abstract:Conformational computations of the synthesized H-Leu-His-Lys-Leu-Gln-Thr-NH2 and H-Ala-D-Ala-Lys-Leu-Ala-Thr-NH2 peptide sequences corresponding to the 16–21 fragment of salmon calcitonin II and its highly active analog that exhibits an analgesic activity were performed. The molecular dynamics method with the AMBER force field was used to trace changes in the geometric parameters of the two molecules over the course of 1500 ps. The conformation of the molecular skeletons underwent no radical changes during computations, and relative flexibility was only revealed in the Lys3, Leu4, and Thr6 side chains.
Document Type: Research Article
Publication date: May 1, 2005