Synthesis of 2-(Pyrazol-1-yl)pyrimidine Derivatives by Cyclocondensation of Ethyl Acetoacetate (6-Methyl-4-oxo-3,4-dihydropyrimidin-2-yl)hydrazone with Aromatic Aldehydes
Authors: Erkin, A. V.; Krutikov, V. I.; Chubraev, M. A.
Source: Russian Journal of General Chemistry, Volume 74, Number 3, March 2004 , pp. 423-427(5)
Publisher: MAIK Nauka/Interperiodica
Abstract:2-(4-Arylidene-3-methyl-5-oxo-4,5-dihydropyrazol-1-yl)-6-methylpyrimidin-4(3H)-ones were obtained by reaction of ethyl acetoacetate (6-methyl-4-oxo-3,4-dihydropyrimidin-2-yl)hydrazone with aromatic aldehydes. Successful cyclization occurs with aldehydes containing an auxochromic substituent in the para position.
Document Type: Research Article
Affiliations: St. Petersburg State Institute of Technology, St. Petersburg, Russia
Publication date: 2004-03-01