Reaction of Alkyl(dialkoxyphosphoryl)alkanimidates with Phenyl Isothiocyanate
Authors: Shishkin V.E.; Mednikov E.V.; No B.I.
Source: Russian Journal of General Chemistry, Volume 73, Number 8, August 2003 , pp. 1204-1207(4)
Publisher: MAIK Nauka/Interperiodica
Abstract:A slow reaction of C-phosphorylated imidates with phenyl isothiocyanate proceeds selectively via nucleophilic addition by the carbon-nitrogen double bond, involving the = N-H group, to form thiourea derivatives in yields of up to 77%. The reaction accelerates in the presence of triethylamine. Reaction kinetics were studied. It was found the the rate constants vary in parallel with basicity (pKa) of the starting imidates.
Document Type: Research article
Publication date: 2003-08-01