Phosphonium Ylides Stabilized with Cyano Group and 5-Acylamino-4-phenyl-2-thiazolyl Residue

Authors: Smolii, O.B.; Panchishin, S.Y.; Pirozhenko, V.V.; Drach, B.S.

Source: Russian Journal of General Chemistry, Volume 71, Number 11, November 2001 , pp. 1734-1736(3)

Publisher: MAIK Nauka/Interperiodica

Buy & download fulltext article:


Price: $45.00 plus tax (Refund Policy)


Available ylide reagent Ph_3P = C(CN)C(S)NH_2 readily enters cyclocondensation with N-(chlorophenacyl)benzamide and its analogs. By this route were prepared new stabilized phosphonium ylides containing cyano group and the corresponding 5-acylamino-4-phenyl-2-thiazolyl fragment. All these compounds even under standard conditions are dephosphorylated under the action of hydrogen chloride in acetic acid to form 5-acylamino-4-phenyl-2-cyanomethylthiazoles in high yields. Their structure was proved by spectroscopic studies and independent synthesis.

Document Type: Regular Paper

Affiliations: Institute of Bioorganic and Petroleum Chemistry, National Academy of Sciences of Ukraine, Kiev, Ukraine

Publication date: November 1, 2001

Related content



Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content

Text size:

A | A | A | A
Share this item with others: These icons link to social bookmarking sites where readers can share and discover new web pages. print icon Print this page