Synthesis and Transformations of 4-Phosphorylated 2-Alkyl(aryl)-5-hydrazinooxazoles
Authors: Brovarets, V.S.; Vydzhak, R.N.; Pil'o, S.G.; Zyuz', K.V.; Drach, B.S.
Source: Russian Journal of General Chemistry, Volume 71, Number 11, November 2001 , pp. 1726-1728(3)
Publisher: MAIK Nauka/Interperiodica
Abstract:Treatment of 1-phosphorylated 2,2-dichloroethenylcarboxamides with excess hydrazine hydrate gives in high yields phosphorylated derivatives of 2-alkyl(aryl)-5-hydrazinooxazoles containing the P(O)(OCH_3)_2, P(O)(OC_2H_5)_2, and P^+(C_6H_5)_3ClO_4^- groups in the 4-position of the ring. The presence of the hydrazine group in these oxazole derivatives was confirmed not only by the spectral data, but also by the reactions with p-toluic aldehyde, p-toluic chloride, and phenyl isothiocyanate.
Document Type: Regular Paper
Affiliations: Institute of Bioorganic and Petroleum Chemistry, National Academy of Sciences of Ukraine, Kiev, Ukraine
Publication date: November 2001